Contact
Research interests
- Spatio-temporal pattern formation in complex system geometries
- Mass-conserving reaction–diffusion systems
- MinCDE protein dynamics in vivo and in vitro
- Biofilms and quorum sensing
- Machine Learning methods for the analysis of quantitative experimental data
Curriculum Vitae
- from 09/2018: Postdoc at Microsoft Research Cambridge (UK), Biological Computation Group
- 09/2017 - 08/2018: Postdoc, Frey Group
- 09/2017: PhD in Physics, Frey Group
Dissertation: Towards a Theory for Pattern Formation in Reaction Diffusion Systems - 09/2010: Diploma in Physics, Frey Group
Publications
2023
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Redundancy and the role of protein copy numbers in the cell polarization machinery of budding yeast
Fridtjof Brauns Leila Margarita Iñigo de la Cruz Karl-Gustav Daalman Ilse de Bruin Jacob Halatek Liedewij Laan Erwin Frey [bioRxiv:2020.09.09.290510]
2022
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Bridging scales in a multiscale pattern-forming system
Laeschkir Würthner* Fridtjof Brauns* Grzegorz Pawlik Jacob Halatek Jacob Kerssemakers Cees Dekker Erwin Frey [arXiv:2111.12043]
2021
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Bulk-surface coupling identifies the mechanistic connection between Min-protein patterns in vivo and in vitro
Fridtjof Brauns* Grzegorz Pawlik* Jacob Halatek* Jacob W.J. Kerssemakers Erwin Frey+ Cees Dekker+ [bioRxiv:10.1101/2020.03.01.971952] -
Diffusive coupling of two well-mixed compartments elucidates elementary principles of protein-based pattern formation
Fridtjof Brauns Jacob Halatek Erwin Frey [arXiv:2010.15095] -
Wavelength selection by interrupted coarsening in reaction-diffusion systems
Fridtjof Brauns Henrik Weyer Jacob Halatek Junghoon Yoon Erwin Frey [arXiv:2005.01495]
2020
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Phase-space geometry of mass-conserving reaction-diffusion dynamics
Fridtjof Brauns* Jacob Halatek* Erwin Frey [arXiv:1812.08684] -
Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
Raphaela Geßele Jacob Halatek Laeschkir Würthner Erwin Frey [bioRxiv:10.1101/451880]
2019
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Design of biochemical pattern forming systems from minimal motifs
Philipp Glock Fridtjof Brauns Jacob Halatek Erwin Frey Petra Schwille [bioRxiv:10.1101/666362]
2018
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Rethinking Pattern Formation in Reaction-Diffusion Systems
Jacob Halatek Erwin Frey [F1000 Article Recommendation] -
MinE conformational switching confers robustness on self-organized Min protein patterns
Jonas Denk* Simon Kretschmer* Jacob Halatek* Caroline Hartl Petra Schwille+ Erwin Frey+ [F1000Prime recommended] -
Self-organization principles of intracellular pattern formation
Jacob Halatek Fridtjof Brauns Erwin Frey [arXiv:1802.07169] -
Protein Pattern Formation
Erwin Frey Jacob Halatek Simon Kretschmer Petra Schwille [arXiv:1801.01365]
2016
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Multistability and dynamic transitions of intracellular Min protein patterns
Fabai Wu* Jacob Halatek* Matthias Reiter Enzo Kingma Erwin Frey+ Cees Dekker+ -
Geometry induced protein pattern formation
Dominik Thalmeier Jacob Halatek Erwin Frey
2014
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Effective two-dimensional model does not account for geometry sensing by self-organized proteins patterns
Jacob Halatek Erwin Frey [arxiv:1403.5934]