Can we build predictive theories for self-organizing systems—spanning fluids, diffusion–reaction systems, soft/active matter, and living systems—without tracking every microscopic detail? Yes: by exploiting universality, symmetry, and conservation laws, and coarse-graining to reveal instability mechanisms, mesoscopic laws, and scaling behavior.
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The murine thymus exhibits a complex, convoluted medullary morphology essential for central tolerance, yet the physical principles underlying this structure have remained unclear. In this work, we present a theoretical model that explains how the medulla self-organizes through feedback between thymocyte signaling and epithelial growth.
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