Many of a cell’s functional constituents such as organelles need to be distributed and organized in a highly orchestrated manner within the cell. To this end, they are actively transported by molecular motors on the two cytoskeletal components: microtubules and actin filaments. Although it is long recognized that motion and an interplay of the dynamics on these two cytoskeletal components is vital to ensure the proper organization of proteins within a cell, general mechanisms that govern the cell-wide distribution of organelles are elusive. In this project we addressed this problem for the case of dark pigment organelles in highly specialized skin cells of fish and amphibians. By a redistribution of these pigment organelles within a cell, the corresponding animals are capable of adapting their skin color to environmental factors. In collaboration with the group of Dr. Zeynep Ökten at the TU Munich, we related biomolecular changes of individual motors that move the pigment organelles on the cytoskeleton to a cell-wide distribution of the organelles.